The ALLIANCE trial
The ALLIANCE program consists of multiple clinical trials. The ALLIANCE trial (pivotal study) will explore the safety and effectiveness of the Edwards SAPIEN X4 transcatheter heart valve system for patients with symptomatic, severe, calcific aortic stenosis. The ALLIANCE aortic valve-in-valve trial will be conducted among subjects who have a failing aortic surgical or transcatheter bioprosthetic valve. This trial is currently enrolling.