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Clinical research and trials

doctor and old patient
doctor and old patient
doctor and old patient

Explore our ongoing clinical trials

Welcome to the Edwards Lifesciences Clinical Research program. Here you can search all Edwards active clinical trials, understand what treatments and disease states are being investigated, and learn about trial design and inclusion criteria. We're glad you're here.

clasp II tr trial
clasp II tr trial
clasp II tr trial

The CLASP II TR trial

The CLASP II TR clinical trial study is to determine the safety and effectiveness of the Edwards PASCAL transcatheter valve repair system, a device designed to repair the tricuspid valve with no open heart surgery. This trial is meant for patients with severe, symptomatic tricuspid regurgitation, despite current medical therapy.

View the CLASP II TR trial clinical trial siteView details on ClinicalTrials.gov
clasp trial
clasp trial
clasp trial

The CLASP IID trial

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL transcatheter valve repair system compared with Abbott MitraClip in patients with degenerative mitral regurgitation.

View the CLASP IID trial clinical trial siteView details on ClinicalTrials.gov
clasp iif trial
clasp iif trial
clasp iif trial

The CLASP IIF trial

A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL transcatheter valve repair system compared with Abbott MitraClip in patients with functional mitral regurgitation.

View the CLASP IIF trial clinical trial siteView details on ClinicalTrials.gov
early tavr trial
early tavr trial
early tavr trial

The EARLY TAVR trial

The EARLY TAVR trial has completed enrollment. The EARLY TAVR trial will examine the safety and effectiveness of the Edwards SAPIEN 3/ SAPIEN 3 Ultra transcatheter heart valve (THV) versus clinical surveillance in patients with severe calcific aortic stenosis without symptoms.

View the EARLY TAVR trial clinical trial siteView details on ClinicalTrials.gov
ENCIRCLE Trial
ENCIRCLE Trial
ENCIRCLE Trial

The ENCIRCLE trial

This clinical trial will evaluate the safety and effectiveness of the SAPIEN M3 system in patients with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable.

View the ENCIRCLE trial clinical trial siteView details on ClinicalTrials.gov
The HPI CARE Trial Logo
The HPI CARE Trial Logo
The HPI CARE Trial Logo

The HPI CARE trial

The HPI Care trial is designed to determine whether the use of the Acumen Hypotension Prediction Index (HPI) software to guide hemodynamic management in patients undergoing cardiac surgery requiring cardiopulmonary bypass reduces the mean duration of hypotension (defined as MAP < 65 mmHg) from the post-bypass period in the cardiac operating room (OR) and the cardiovascular intensive care unit (CVICU). The Acumen HPI software is used on-label in the HPI-CARE Trial and is not an investigational device.

View the HPI CARE trial clinical trial siteView details on ClinicalTrials.gov
The HPI SMART-BP Trial Logo
The HPI SMART-BP Trial Logo
The HPI SMART-BP Trial Logo

The HPI SMART-BP trial

The HPI Smart-BP trial is a multicenter, interventional, randomized trial to determine if the use of a protocolized strategy using advanced hemodynamic monitoring with Acumen Hypotension Prediction Index (HPI) software guidance for intraoperative hemodynamic management reduces postoperative complication rate in moderate- to high-risk noncardiac surgery. The Acumen HPI software is used on-label in the HPI SMART-BP Trial and is not an investigational device.

View the HPI SMART-BP trial clinical trial siteView details on ClinicalTrials.gov
The PROGRESS Trial Logo
The PROGRESS Trial Logo
The PROGRESS Trial Logo

The PROGRESS trial

The PROGRESS trial is a prospective, randomized, controlled trial to evaluate the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) versus clinical surveillance in patients with moderate calcific aortic stenosis.

View the PROGRESS trial clinical trial siteView details on ClinicalTrials.gov
TRISCEND II Trial
TRISCEND II Trial
TRISCEND II Trial

The TRISCEND II trial

The TRISCEND II clinical trial is to determine the safety and effectiveness of the EVOQUE valve, a device designed to replace the tricuspid valve with no open heart surgery. This trial is for patients with severe or greater tricuspid regurgitation.

View the TRISCEND II trial clinical trial siteView details on ClinicalTrials.gov
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contact us lady
contact us lady

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Important safety information

CAUTION – Investigational devices. Limited by Federal (United States) law to investigational use.

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