The MITRIS RESILIA valve
Is designed for potential future transcatheter interventions
With increasing life expectancy, implementing a lifelong management strategy is becoming increasingly important.1,2 This is especially true for young patients who are more likely to outlive their tissue valves and may require re-interventions over time.2 Selecting the right first valve is critical, as it can significantly influence the feasibility of future treatments.2,3
The MITRIS RESILIA valve offers clearer visualisation for valve-in-valve (ViV) positioning vs Abbott EpicTM and Medtronic MosaicTM porcine valves*4
In a head-to-head study involving pigs who have undergone ViV transcatheter mitral valve replacement (TMVR), the MITRIS RESILIA valve’s cobalt chromium band provided superior visibility of the entire stent and frame under fluoroscopy for easy identification of the landing zone compared with the Abbott EpicTM and Medtronic MosaicTM porcine valves.4
Medtronic MosaicTM valve (27 mm)
MITRIS RESILIA valve
Adapted from Wang DD, et al. 2022.4
The MITRIS RESILIA valve resulted in the lowest left ventricular outflow tract (LVOT) peak/ mean gradients vs Abbott EpicTM and Medtronic MosaicTM porcine valves*4
Due to the small sample size, only descriptive data is presented with no further statistical analysis.
The MITRIS RESILIA valve following TMVR ViV did not result in LVOT obstruction, with no clinically significant LVOT obstruction observed across the valves post-procedure. Furthermore, the MITRIS RESILIA valve had the lowest peak/mean LVOT gradients vs Abbott EpicTM and Medtronic MosaicTM porcine valves.4
The MITRIS RESILIA valve enabled optimal expansion of the transcatheter heart valve (THV) following TMVR ViV *4
The column-like design of the MITRIS RESILIA valve enabled more uniformity in the expansion of the THV compared with Abbott EpicTM and Medtronic MosaicTM porcine valves.4
Due to the small sample size, only descriptive data is presented with no further statistical analysis.
The more uniform expansion of the THV resulted in more laminar flow, optimal THV leaflet opening, less THV leaflet pinwheeling, and lower post-ViV mitral peak/mean gradients than Abbott EpicTM and Medtronic MosaicTM porcine valves. 4
| MITRIS RESILIA valve | Abbott EpicTM valve (27 mm) | Medtronic MosaicTM valve (27 mm) | |
| Post TMVR ViV mitral peak gradient (mmHg) | 3.77±0.36 | 15.5±2.55 | 9.97±3.19 |
| Post TMVR ViV mitral mean gradient (mmHg) | 2.2±0.25 | 7.09±1.13 | 5.32±1.31 |
Due to the small sample size, only descriptive data is presented with no further statistical analysis.
Download the MITRIS RESILIA valve brochure to find out more
*12 Yorkshire pigs received comparable valves (27 mm Abbott EpicTM valve [n=4]; 27 mm Medtronic MosaicTM valve [n=4]; 25 mm MITRIS RESILIA valve [n=4]) followed by TMVR ViV with a 26 Edwards Sapien3 valve. Post-ViV, suprasternal transoesophageal echocardiography studies were performed to assess haemodynamic function, followed by gated contrast computed tomography (CT). To ensure comparable anatomical and haemodynamic study conditions, pigs with a >6% anatomical variation were excluded from the study.4
Abbreviations
CAD, computer-aided design; CT, computed tomography; LVOT, left ventricular outflow tract; THV, transcatheter heart valve; TMVR, transcatheter mitral valve replacement; ViV, valve-in-valve.
References
- Wise J. BMJ. 2024;385:q1126.
- Jubran A, et al. Can J Cardiol. 2023; S0828-282X(23)01662-8.
- Tarantini G & Fovino LN. JACC Cardiovasc Interv. 2021;14(15)1727–30.
- Wang DD, et al. Catheter Cardiovasc Interv. 2022;99(3):934–2.
Medical device for professional use.
Medical device for professional use.
For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).
PP--EU-11860 v1.0