Mitral valve repair:
Residual MR matters

In the early days of transcatheter mitral valve repair, the goal was a successful procedure that reduced mitral regurgitation (MR) to less than 3+; residual MR grade 2+ was considered acceptable.1,2

Compelling new data on more than 3,700 patients show that residual MR grades 0–1+ are significantly associated with superior patient outcomes when compared with residual MR 2+, including reduced mortality and rehospitalisation.3–5

Click to view MR 0-1+ evidence

Lower MR grades are
within your clasp

PASCAL spacer

More Opportunity, Lower MR Grades

A unique central spacer is designed to block more jet and minimise MR

PASCAL Independent Leaflet Grasping

Independent Leaflet Grasping

Independent actuation and distinct clasp design allow leaflet capture precision while respecting native anatomy

PASCAL elongation feature

Device Elongation

Device enlongation feature optimises subvalvular manoeuvrability when you need it

Get the full story on lower MR grades

See PASCAL performance in the CLASP study data

The CLASP study data offers evidence for achieving residual MR 0–1+ after mitral valve repair6

Graph showing CLASP study data


With most patients achieving residual MR 0-1+6, the PASCAL repair system puts lower MR grades within your clasp.


Click to see the data

See how it works

Watch the PASCAL repair system procedural animation

PASCAL repair system procedural animation

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References
  1. Feldman T, Wasserman HS, Herrmann HC, et al. Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I clinical trial. J Am Coll Cardiol. 2005;46(11):2134–2140.
  2. Feldman T, Foster E, Glower DD, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med. 2011;364(15):1395–1406.
  3. Patzelt J, Zhang W, Sauter R, et al. Elevated mitral valve pressure gradient is predictive of long-term outcome after percutaneous edge-to-edge mitral valve repair in patients with degenerative mitral regurgitation (MR), but not in functional MR. J Am Heart Assoc. 2019;8(13):e011366.
  4. Sorajja P, Vemulapalli S, Feldman T, et al. Outcomes with transcatheter mitral valve repair in the United States. An STS/ACC TVT Registry report. J Am Coll Cardiol. 2017;70(19):2315–2327.
  5. Tabata N, Weber M, Sugiura A, et al. Impact of the leaflet-to-annulus index on residual mitral regurgitation in patients undergoing edge-to-edge mitral repair. JACC Cardiovasc Interv. 2019;12(24):2462–2472.
  6. Lim DS, Kar S, Spargias K, et al. Transcatheter valve repair for patients with mitral regurgitation: 30-day results of the CLASP study. JACC Cardiovasc Interv. 2019;12(14):1369-1378.

For professional use

For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).

For professional use

For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).

Edwards devices placed on the European market meeting the essential requirements referred to in Article 3 of the Medical Device Directive 93/42/EEC bear the CE marking of conformity.

Cardioband Systems are manufactured by Valtech Cardio Ltd. for Edwards Lifesciences.

Caution- Investigational device in the United States. Limited by federal (or United States) law to investigational use.

Edwards, Edwards Lifesciences, the stylized E logo, Cardioband, PASCAL, Valtech, and Valtech Cardio are trademarks or service marks of Edwards Lifesciences Corporation or its affiliates. All other trademarks are the property of their respective owners.

© 2020 Edwards Lifesciences Corporation. All rights reserved. E10754/02-20/TMTT

Edwards Lifesciences • Route de l’Etraz 70, 1260 Nyon, Switzerland • edwards.com

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