Mitral valve repair:
Residual MR matters
In the early days of transcatheter mitral valve repair, the goal was a successful procedure that reduced mitral regurgitation (MR) to less than 3+; residual MR grade 2+ was considered acceptable.1,2
Compelling new data on more than 3,700 patients show that residual MR grades 0–1+ are significantly associated with superior patient outcomes when compared with residual MR 2+, including reduced mortality and rehospitalisation.3–5
Lower MR grades are
within your clasp
More Opportunity, Lower MR Grades
A unique central spacer is designed to block
more jet and minimise MR
Independent Leaflet Grasping
Independent actuation and distinct clasp
design allow leaflet capture precision while
respecting native anatomy
Device Elongation
Device enlongation feature optimises subvalvular manoeuvrability when you need it
See PASCAL performance in the CLASP study data
The CLASP study data offers evidence for achieving residual MR 0–1+ after mitral valve repair6
With most patients achieving residual MR 0-1+6, the PASCAL repair system puts lower MR grades within your clasp.
See how it works
Watch the PASCAL repair system procedural animation
Learn more about Edwards' transcatheter mitral
and tricuspid portfolio
- Feldman T, Wasserman HS, Herrmann HC, et al. Percutaneous mitral valve repair using the edge-to-edge technique: six-month results of the EVEREST Phase I clinical trial. J Am Coll Cardiol. 2005;46(11):2134–2140.
- Feldman T, Foster E, Glower DD, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med. 2011;364(15):1395–1406.
- Patzelt J, Zhang W, Sauter R, et al. Elevated mitral valve pressure gradient is predictive of long-term outcome after percutaneous edge-to-edge mitral valve repair in patients with degenerative mitral regurgitation (MR), but not in functional MR. J Am Heart Assoc. 2019;8(13):e011366.
- Sorajja P, Vemulapalli S, Feldman T, et al. Outcomes with transcatheter mitral valve repair in the United States. An STS/ACC TVT Registry report. J Am Coll Cardiol. 2017;70(19):2315–2327.
- Tabata N, Weber M, Sugiura A, et al. Impact of the leaflet-to-annulus index on residual mitral regurgitation in patients undergoing edge-to-edge mitral repair. JACC Cardiovasc Interv. 2019;12(24):2462–2472.
- Lim DS, Kar S, Spargias K, et al. Transcatheter valve repair for patients with mitral regurgitation: 30-day results of the CLASP study. JACC Cardiovasc Interv. 2019;12(14):1369-1378.
Content relating to Edwards Lifesciences devices is intended for healthcare professionals. Click OK to confirm you are a healthcare professional and proceed, or click Decline to view non-device related content.