Shock matters

Shock in the ICU

Shock, at its most basic level, is the inadequate delivery of oxygen to the tissues, which are dependent upon perfusion, pressure (MAP), and flow.1

Shock is the inadequate delivery of oxygen to the tissues, which are dependent upon perfusion, pressure, and flow.


Shock is common. 1/3 of ICU patients suffer some form of shock.3,4

1/3 of ICU patients suffer some form of shock.

ICU patients presenting with shock have a nearly 40% risk of death.3

ICU patients presenting with shock have a nearly 40% risk of death.

Clinical manifestation of shock

This deadly condition manifests through hypotension, hypo-perfusion, and organ injury.4

Shock manifests through hypotension, hypo-perfusion, and organ injury.

Early identification matters

Various indices may be used to identify patients at risk.5,6,7

Modified shock index (MSI) has been shown to be a predictor of hospital mortality in critically ill and injured patients. There are other indices which may also be used to identify patients at-risk. Common indices:

Modified shock index (MSI) has been shown to be a predictor of hospital mortality in critically ill and injured patients.

Type of shock matters

A primary reason for using advanced hemodynamic parameters for patients in shock, is to identify the type of shock in order to determine the most appropriate therapy.

Prompt identification is essential so that aggressive management can be started. Appropriate treatment is based on an understanding of the underlying pathophysiological mechanisms. 4

There are four primary types of shock: 2,4

Types of shock matter 1Types of shock matter 1
Types of shock matter 2 Types of shock matter 2
Types of shock matter 3 Types of shock matter 3
Types of shock matter 4 Types of shock matter 4

Studies show that individuals with suspected similar diseases (such as heart failure, sepsis, and stroke) present with widely diverse hemodynamic profiles. 8

Trends in advanced parameters provide information on the underlying type of shock and enable clinicians to treat the specific type of shock more effectively.

Trends in advanced parameters provide information on the underlying type of shock.

Managing hemodynamics in shock

Timely intervention is key

Early, adequate hemodynamic support of patients in shock is crucial to prevent worsening organ dysfunction and failure. 4

Correcting arterial hypotension is essential to restore blood pressure and provide adequate cellular metabolism, which is the primary goal of resuscitation.

After correction of hypoxemia and severe anemia, cardiac output (CO) is the principal determinant of oxygen delivery and achieving a CO that is compatible with tissue perfusion is also critical.

Measurements of mixed venous oxygen saturation (ScvO2, SvO2) may also be helpful in assessing the adequacy of the balance between oxygen demand and supply. 4

Arterial Pressure (MAP)

Cardiac Output (CO)

Oxygen supply and demand (SvO2/ScvO2)

Continuous measures and advanced hemodynamic parameters can be used to monitor the critically ill patient and provide additional insights compared to traditional parameters such as CVP, HR, and estimated volume loss alone.1 Shock situations can escalate quickly and advanced hemodynamic monitoring provides insights that enable you to make informed proactive clinical decisions.

Hemodynamic measurements, like those provided by the ClearSight system, FloTrac sensor, Acumen IQ sensor, Edwards oximetry central venous catheter, or the Swan-Ganz catheter working with an advanced monitoring platform, can provide you insights into a patient's cardiovascular function to guide decision-making.

Shock and hypotension

For a patient with shock it's important to monitor blood pressure for hypotension. A hypotensive event may be defined as MAP <65 mmHg for a duration of at least one minute. Blood pressure under this threshold may increase risk of mortality and organ failure.1

The Acumen Hypotension Prediction Index (HPI) software is a first-of-its-kind technology that detects the likelihood of a patient trending towards a hypotensive event before the event occurs. It provides you with insights to understand the root cause and inform a potential course of action for your patient. To learn more visit: Edwards.com/HPI.

HPI is a first-of-its-kind technology that detects the likelihood of a patient trending towards a hypotensive event before the event occurs.

Volume Management

How you manage volume in shock matters

Fluid therapy to increase cardiac output is an essential component of treating any form of shock and should be carefully monitored.4

Individualizing volume management

Preload is the tension of myocardial fibers at the end of diastole, as a result of volume in the ventricle.

Preload: the tension of myocardial fibers at the end of diastole, as a result of volume in the ventricle

Stroke Volume is the volume of blood pumped from the left ventricle per heartbeat.

Stroke Volume (SV): volume of blood pumped from the left ventricle per heartbeat


Stroke volume measurement with Edwards devices, such as the ClearSight system, FloTrac system, and Acumen IQ system, enable an individualized approach for administering fluid until SV reaches a plateau on the Frank-Starling curve, to help prevent hypovolemia and excessive fluid administration.

Advanced hemodynamic parameters such as SV and stroke volume variation (SVV), are key to optimal fluid administration and keeping patients in the optimal volume range. They are more informative than conventional parameters (such as blood pressure or central venous pressure) in determining fluid responsiveness and may help clinicians avoid excessive and insufficient fluid administration.

When managing perfusion, stroke volume can be optimized using the patient’s own Frank-Starling curve.

Stroke volume optimization
When managing perfusion, stroke volume can be optimized using the patient’s own Frank-Starling curve — a plot of SV vs. preload.

The patient’s location on his or her Frank-Starling curve can be determined by measuring ΔSV.

With the FloTrac sensor, Acumen IQ sensor, or ClearSight system, the patient’s location on his or her Frank-Starling curve can be determined by measuring ΔSV in response to change in preload using fluid bolus challenge or passive leg raise.

Stroke volume variation optimizationImage

Stroke volume variation optimization

For control-ventilated patients, SVV has proved to be a highly sensitive and specific indicator for pre-load responsiveness, serving as an accurate marker of patient status on the Frank-Starling curve.

Additional product information

Edwards offers a range of clinical decision support solutions that provide advanced hemodynamic parameters used to manage critically ill patients.


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References:
  1. Seuss & Pinsky. Hemodynamic Monitoring for the Evaluation and Treatment of Shock: What Is the Current State of the Art? Semin Respir Crit Care Med 2015. 890-898.
  2. Cecconi, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Int Care Med 2014. 1795 - 1815.
  3. Sakr Y, Reinhart K, Vincent JL, et al. Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med 2006. 589 – 597.
  4. Vincent & De Backer. Circulatory Shock. New England Journal of Medicine. 2013. 1726-1734.
  5. Singh, et al. Correlation of shock index and modified shock index with the outcome of adult trauma patients: a prospective study of 9860 patients. N Am J Med Sci 2014.
  6. Sminschney, et al. Elevated modified shock index within 24 hours of ICU admission is an early indicator of mortality in the critically ill. J Int Care Med 2016; 582-588.
  7. Jiang, et al. Respiratory adjusted shock index for identifying occult shock and level of Care in Sepsis Patients. Amer J Emerg Med 2018.
  8. Nowak, RM ea al. Noninvasive hemodynamic monitoring in emergency patients with suspected heart failure, sepsis and stroke: the premium registry. West J Emerg Med 2014, 786-794.

Important safety information

Caution: Federal (United States) law restricts this device to sale by or on the order of a physician.
See Instructions For Use (IFU) / Directions For Use (DFU) for full prescribing information, including indications, contraindications, warnings, precautions and adverse events.

Important safety information

Caution: Federal (United States) law restricts this device to sale by or on the order of a physician.
See Instructions For Use (IFU) / Directions For Use (DFU) for full prescribing information, including indications, contraindications, warnings, precautions and adverse events.

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