Edwards Lifesciences: COVID-19 support

As understanding of the novel SARS-CoV-2 virus and resulting COVID-19 disease evolves almost daily, clinicians around the world are in constant discussions on how best to care for, treat, and manage patients with COVID-19 and resulting sepsis, septic shock, and/or acute respiratory distress syndrome (ARDS). Their focus is on supporting ideal oxygenation and maintaining appropriate fluid balance to minimize severe life-threatening complications. Included within this newsletter are resources that can help clinicians minimize the complexity of managing fluids in patients hospitalized with COVID-19.


The following is an example of how some hospitals are initially treating preload/volume with emphasis on the stroke volume response approach.

Stroke volume optimization % change in stroke volume (ΔSV) is a sensitive method for assessing preload responsiveness in all patients.

“No monitoring device, no matter how simple or complex, invasive or noninvasive, inaccurate or precise will improve outcomes unless coupled to a treatment, which itself improves outcome.”1

Pinsky and Payen

Hemodynamic parameters can aid during the screening and treatment of critically ill patients with sepsis, acute respiratory distress syndrome (ARDS), or COVID-19.

Normal hemodynamic parameters and laboratory values

Created to support clinicians caring for surgical patients or the critically ill, the handy chart brings hemodynamic parameters and laboratory values together in one place.
Download the Normal Values card


Educational references and resources
Shock Matters

While most people with COVID-19 develop mild or uncomplicated illness, approximately 14% develop severe disease requiring hospitalization and oxygen support and 5% require admission to an intensive care unit. In severe cases, COVID-19 can be complicated by acute respiratory disease syndrome (ARDS), sepsis and septic shock, multiorgan failure, including acute kidney injury and cardiac injury.”2 “In a study of 150 patients from 2 hospitals in Wuhan, China, shock was a major reason for death in 40%, and may, at least in part, be due to fulminant myocarditis.”3

Type of shock matters

A primary reason for using advanced hemodynamic parameters for patients in shock, is to identify the type of shock in order to determine the most appropriate therapy.

Prompt identification is essential so that aggressive management can be started. Appropriate treatment is based on an understanding of the underlying pathophysiological mechanisms.4

Studies show that individuals with suspected similar diseases (such as heart failure, sepsis, and stroke) present with widely diverse hemodynamic profiles.5

Trends in advanced parameters provide information on the underlying type of shock and enable clinicians to treat the specific type of shock more effectively.

  • MAP -Mean Arterial Pressure
  • CO/SV - Cardiac Output/Stroke Volume
  • DO2 - Global Oxygen Delivery
  • CVP - Central Venous Pressure
  • MPAP - Mean Pulmonary Artery Pressure
  • PCWP - Pulmonary Capillary Wedge Pressure
  • SVR - Systemic Vascular Resistance
  • HPI - Hypotension Prediction Index
  • dP/dt - Systolic Slope
  • Eadyn - Dynamic arterial elastance

Timely intervention is key

Early, adequate hemodynamic support of patients in shock is crucial to prevent worsening organ dysfunction and failure.4

Correcting arterial hypotension is essential to restore blood pressure and provide adequate cellular metabolism, which is the primary goal of resuscitation.

After correction of hypoxemia and severe anemia, cardiac output (CO) is the principal determinant of oxygen delivery and achieving a CO that is compatible with tissue perfusion is also critical.

Measurements of mixed venous oxygen saturation (ScvO2, SvO2) may also be helpful in assessing the adequacy of the balance between oxygen demand and supply.4,6

Learn more

COVID-19 updates

TopMed Talk COVID-19 podcasts

References
  1. Pinsky and Payen, doi.org/10.1007/3-540-26900-2_1.
  2. World Health Organization. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: Interim guidance V 1.2. (accessed 3.23.20).
  3. Alhazzani, Rhodes, et al. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). European Society of Intensive Care Medicine and the Society of Critical Care Medicine 2020.
  4. Vincent & De Backer. Circulatory Shock. New England Journal of Medicine. 2013. 1726-1734.
  5. Nowak, RM ea al. Noninvasive hemodynamic monitoring in emergency patients with suspected heart failure, sepsis and stroke: the premium registry. West J Emerg Med 2014, 786-794.
  6. Zaja, J. Venous oximetry. Signa Vitae 2007; 2 (1): 6-10.

Learn more

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