The clarity to consistently maintain your patients in the
optimal volume range. The control to reduce variability in
volume administration.
Dynamic and flow-based
parameters in the OR 
Advanced hemodynamic parameters
used in a clinician-directed PGDT
protocol are key to optimal volume
administration. 31
ClearSight System
FloTrac System
Swan-Ganz Catheter
A pioneer in hemodynamic management, Edwards offers integrated hemodynamic
monitoring solutions that can be utilized perioperatively from the OR to the ICU.

Edwards’ hemodynamic monitoring solutions provide
advanced hemodynamic parameters shown to be more
informative in determining fluid responsiveness than
conventional pressure-based parameters, such as mean
arterial pressure (MAP) and central venous pressure (CVP). 1,2

Each of Edwards’ monitoring solutions offers continuous
dynamic and flow-based information which may be used in
Perioperative Goal-Directed Therapy (PGDT) to
consistently maintain your moderate to high-risk surgery
patients in the optimal volume range. 3

FloTrac System
ClearSight System
Swan-Ganz Catheter

Based on the complexity of each procedure, and patient risk factors, choose your preferred dynamic and
flow-based parameters and the appropriate Edwards’ hemodynamic monitoring solution
to suit your
clinical approach and your moderate to high-risk surgical patients’ needs.

Edwards delivers an array of product support, tools and educational resources to help you advance patient care by extending
the benefits of reduced variability in volume administration to a broader range of patients, and more moderate
to high-risk surgical procedures.

The evidence-based value of maintaining your patient in the optimal volume range through Perioperative Goal-Directed Therapy (PGDT) 4-7
controlled trials
Download full list of studies
Download full list of studies

30+ randomized controlled trials and 14+ meta-analyses have demonstrated clinical benefits of hemodynamic optimization utilizing a PGDT protocol and advanced parameters over standard volume management, including reducing post-surgical complications across a wide range of moderate to high-risk surgical populations. 4-7

Additionally, an extensive body of clinical evidence shows that goal-directed hemodynamic optimization of high-risk patients, initiated in the OR and continued in the ICU, not only improves short-term outcomes, but also increases long-term survival. 8-27

How to consistently maintain your patient
in the optimal volume range.
Frank-Starling relationship between
preload and stroke volume (SV)

Optimal volume management is possible when dynamic and
flow-based parameters
are used within a protocol such as
Perioperative Goal-Directed Therapy (PGDT). 3,28-30

Managing volume administration is not the same as
consistently maintaining your patient in the optimal volume
range. 3,28,33-34
Benefits of advanced hemodynamic parameters
in guiding volume administration.

Deviations from hemodynamic stability may increase with more invasive procedures
and/or more severe clinical conditions.
Continuous access to advanced hemodynamic
parameters offers immediate insight into patient physiologic status, giving you the clarity to
make more informed volume administration decisions to help you consistently maintain your
patients in the optimal volume range.3,8,23,25,26,38-42

Advanced hemodynamic parameters versus
conventional care.

Conventional volume management, based on standard
monitoring including central venous pressure (CVP) , is
suboptimal. 1,2

Clinical studies have shown CVP is not able to predict fluid
responsiveness1 and that changes in blood pressure cannot
be used to track changes in stroke volume (SV) or in cardiac
output (CO) induced by volume expansion. 2

Stroke Volume Variation (SVV) has demonstrated a higher
sensitivity and specificity in the assessment of circulating
blood volume when compared to conventional indicators of
volume status (HR, MAP, CVP) . 16,20,32

Optimization strategies

Stroke Volume Optimization (SV) 11,16-19,21-26

Stroke volume measurement with the ClearSight and FloTrac
systems enables an individualized approach for administering
fluid until SV reaches a plateau on the Frank-Starling curve, to
prevent hypovolemia and excessive fluid administration.

Stroke Volume Variation Optimization (SVV) 25

For control-ventilated patients, SVV has proved to be a highly
sensitive and specific indicator for pre-load responsiveness,
serving as an accurate marker of patient status on the
Frank-Starling curve.

Oxygen Delivery Optimization (DO 2 with CCO) 23

Continuous cardiac output (CCO) measured by the ClearSight
and FloTrac systems can be used (in combination with SaO 2
and hemoglobin) to monitor and optimize DO 2 with fluid
(including red blood cells) and inotropic agents.

SV protocol studies Abdominal Bowel Cardiac Cystectomy General Hip Trauma Vascular
Bisgaard 2012 *
Scheeren 2012 *
Pillai 2011 *
Jhanji 2010 *
Chytra 2007 *
Noblett 2006 *
Wakeling 2005 *
McKendry 2004 *
Conway 2002 *
Gan 2002 *
Venn 2002 *
Sinclair 1997 *
Mythen 1995 *
Mechanical Ventilation 35,36

Currently, literature supports the use of SVV only on patients who are 100% mechanically (control mode) ventilated with tidal volumes of more than 8cc/kg and fixed respiratory rates.

Spontaneous Breathing 35,36

Currently, literature does not support the use of SVV with patients who are spontaneously breathing due to the irregular nature of rate and tidal volumes.

Arrhythmias 35,36

Arrhythmias can dramatically affect SVV values. Thus, the utility of SVV as a guide for volume resuscitation is greatest in absence of arrhythmias.

PEEP 35,36

Increasing levels of positive end expiratory pressure (PEEP) may cause an increase in SVV, the effects of which may be corrected by additional volume resuscitation if warranted.

Vascular Tone 35,36

The effects of vasodilatation therapy may increase SVV and should be considered before treatment with additional volume.
SVV protocol studies Abdominal Abdominal and vascular Cardiac Thoracic
Goepfert 2013 *
Zhang 2013 *
Zheng 2013 *
Ramsingh 2012 *
Scheeren 2012 *
Benes 2010 *
Mayer 2009 *
DO 2 protocol studies Abdominal General General and Vascular Hepatectomy Hip Trauma Vascular
Bisgaard 2012 *
Cecconi 2011 *
Jhanji 2010 *
Pearse 2005 *
Lobo 2000 *
Wilson 1999 *
Ueno 1998 *
Boyd 1993 *
Fleming 1992 *
Shoemaker 1988 *
A choice of advanced hemodynamic monitoring solutions.
Helping you advance patient care by providing
valuable insight to help guide volume administration.
ClearSight System
The ClearSight finger cuff extends your opportunity to
offer advanced hemodynamic monitoring,
noninvasively, to a broader range of patients who may
be at risk for post-surgical complications. Learn more
FloTrac System
The FloTrac sensor is the practical, reliable
hemodynamic monitoring solution trusted on over 2
million patients worldwide and used by more clinicians
than any other volume management solution.*
Learn more
Swan-Ganz Catheter

The Swan-Ganz pulmonary artery catheter gives you the clarity of a comprehensive hemodynamic profile delivered by
a single monitoring solution. It allows you to continually assess flow, pressure and oxygen delivery and consumption, to assist your early evaluation. For a continuous view of cardiac function that can enable earlier intervention in your critically complex patients, choose the parameters that best suit your clinical approach and your patient's need. Learn more
EV1000 Clinical Platform

The EV1000 clinical platform clearly and simply presents your patient’s physiologic
status, giving you the clarity to make more informed volume administration
decisions. Get continuous access to clinically validated parameters * by using the
EV1000 clinical platform with the ClearSight system , FloTrac sensor , PreSep and
PediaSat oximetry catheters and VolumeView set.
* Clinical parameters include CCO, SV, SVV, ScvO2, CO, GEDV, GEF, EVLW, RVEDV, RVEF
Clarity In Every Moment
A choice of hemodynamic monitoring options
to meet your clinical needs.
* Sample protocols not intended as clinical guidance. Additional protocols have been
published. For a full listing of all studies, please contact your Edwards Lifesciences
sales representative.
Resources to help your hospital advance patient care
through more informed volume administration.
I would like to trial a
to help my
hospital extend advanced
hemodynamic monitoring
to more patients.
Set up a demonstration
to increase my surgical
team’s proficiency in
hemodynamic parameters.
Help me learn more
about using advanced
hemodynamic parameters.
Have a representative
call me.
Sign me up for this and
future webinars–PGDT
Compliance: Am I really
optimizing my patients?
Know more. Know now.

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for some common sense. Crit Care Med 2013
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expansion in the perioperative period? Anesthesiology 2013
3. Bellamy MC. Wet, dry or something else? Br J Anaesth 2006;97(6):755-757
4. Grocott et al. Perioperative increase in global blood flow to explicit defined goals and outcomes after surgery: a
Cochrane systematic review. Br J Anaesth 2013
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major surgery: a meta-analysis of randomized controlled trials. Br J Anaesth 2009; 103: 637–46
6. Dalfino L, Giglio MT, Puntillo F, Marucci M, Brienza N. Haemodynamic goal-directed therapy and postoperative
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Analgesia 2012
8. Shoemaker WC, et al. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical
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9. Boyd O, et al. A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality
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10. Mythen M, Webb A. Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion
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11. Sinclair S, James S, Singer M. Intraoperative intravascular volume optimization and length of hospital stay after repair of
proximal femoral fracture: randomised controlled trial. AMJ.1997;315:909–912.
12. Ueno S, et al. Response of patients with cirrhosis who have undergone partial hepatectomy to treatment aimed at
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15. Pölönen P, Ruokonen E, Hippeläinen M, Pöyhönen M, Takala J. A prospective, randomized study of goal-oriented
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17. Venn R, Richardson P, Poloniecki J, Grounds M, Newman P. Randomized controlled trial to investigate influence of the
fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures. Br J Anaesth.
18. Conway D, Mayall R, Abdul-Latif M, Gilligan S, Tackaberry C. Randomised controlled trial investigating the influence of
intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery. Anaesthesia.
19. McKendry M, McGloin H, Saberi D, Caudwell L, Brady A, Singer M. Randomised controlled trial assessing the impact of
a nurse delivered, flow monitored protocol for optimization of circulatory status after cardiac surgery. BMJ.
20. Pearse R, et al. Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. Crit
Care. 2005;R687–693.
21. Wakeling H, McFall M, Jenkins C, Woods W, Barclay G, Fleming S. Intraoperative oesophageal Doppler-guided fluid
management shortens postoperative hospital stay after major bowel surgery. Br J Anaesth. 2005;95(5):634–642.
22. Noblett S, Snowden C, Shenton B, Horgan A. Randomized clinical trial assessing the effect of Doppler-optimized fluid
management on outcome after elective colorectal resection. BJS. 2006;93(9):1069–1076.
23. Donati A, Loggi S, Preiser J-C, Orsetti G, Munch C, Gabbanelli V, Pelaia P, Pietropaoli P. Goal-directed intraoperative
therapy reduces morbidity and length of hospital stay in high-risk surgical patients. Chest. 2007;132:1817–1824.
24. Chytra I, Pradl R, Bosman R, Pelnar P, Kasal E, Zidkova A. Esophageal Doppler-guided fluid management decreases
blood lactate levels in multiple-trauma patients: a randomized controlled trial. Crit Care. 2007;11:R24.
25. Benes J, et al. Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of
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26. Cecconi M, Fasano N, Langiano N, Divella M, Costa M, Rhodes A, Della Rocca G. Goal directed haemodynamic
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28. Cannesson M. Arterial pressure variation and goal-directed fluid therapy. J Cardiothorac Vasc Anesth
29. Berkenstadt H, et al. Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery.
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30. Michard F. changes in arterial pressure during mechanical ventilation. Anesthesiology. 2005;103:419-428.
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